Zollinger-Ellison syndrome is caused by which type of tumor?

Zollinger-Ellison syndrome is caused by which type of tumor?

• A. Gastrin-secreting tumor (gastrinoma) in the pancreas or duodenum
• B. Adrenal tumor
• C. Pituitary tumor
• D. Thyroid tumor

Answer: (A)

Zollinger-Ellison syndrome is caused by gastrin-secreting tumors called gastrinomas, most often located in the pancreas or the duodenum. The excess gastrin drives hypergastrinemia, which stimulates gastric acid production by parietal cells, leading to multiple, often recurrent peptic ulcers and sometimes diarrhea. The other tumor types listed do not cause this pattern of hypergastrinemia and acid hypersecretion, so they’re not the source of Zollinger-Ellison syndrome.

Zollinger-Ellison syndrome is caused by gastrin-secreting tumors called gastrinomas, most often located in the pancreas or the duodenum. The excess gastrin drives hypergastrinemia, which stimulates gastric acid production by parietal cells, leading to multiple, often recurrent peptic ulcers and sometimes diarrhea. The other tumor types listed do not cause this pattern of hypergastrinemia and acid hypersecretion, so they’re not the source of Zollinger-Ellison syndrome.