Which treatment options have been used for Peyronie’s disease?

Which treatment options have been used for Peyronie’s disease?

• A. Antibiotics only
• B. Vitamin E and potassium aminobenzoate, colchicine, collagenase injections, surgery
• C. PDE5 inhibitors only
• D. Steroids

Answer: (B)

Peyronie’s disease has a range of treatment approaches that address the fibrous plaque and the resulting curvature, from non-surgical options to surgery for more advanced cases. Oral agents like vitamin E, potassium aminobenzoate, and colchicine have been used in an attempt to slow or modify fibrosis and reduce curvature, though evidence for consistent benefit varies. Collagenase injections directly into the plaque enzymatically break down collagen, which can lessen the curvature in selected patients. Surgery is considered for stable disease with functionally significant deformity or erectile dysfunction not responsive to other therapies, with options such as plaque incision or excision with grafting, tunical plication, or penile prosthesis depending on the situation. Other options like antibiotics or steroids aren’t standard treatments for this condition, and PDE5 inhibitors may help with erections but don’t address the curvature itself. Therefore, the listed combination—vitamin E and potassium aminobenzoate, colchicine, collagenase injections, and surgery—represents the therapies that have been used for Peyronie’s disease.

Peyronie’s disease has a range of treatment approaches that address the fibrous plaque and the resulting curvature, from non-surgical options to surgery for more advanced cases. Oral agents like vitamin E, potassium aminobenzoate, and colchicine have been used in an attempt to slow or modify fibrosis and reduce curvature, though evidence for consistent benefit varies. Collagenase injections directly into the plaque enzymatically break down collagen, which can lessen the curvature in selected patients. Surgery is considered for stable disease with functionally significant deformity or erectile dysfunction not responsive to other therapies, with options such as plaque incision or excision with grafting, tunical plication, or penile prosthesis depending on the situation. Other options like antibiotics or steroids aren’t standard treatments for this condition, and PDE5 inhibitors may help with erections but don’t address the curvature itself. Therefore, the listed combination—vitamin E and potassium aminobenzoate, colchicine, collagenase injections, and surgery—represents the therapies that have been used for Peyronie’s disease.