Which of the following is NOT listed as a common metastatic site for lung cancer in the material?

Which of the following is NOT listed as a common metastatic site for lung cancer in the material?

• A. Brain
• B. Spleen
• C. Liver
• D. Adrenals

Answer: (B)

Lung cancer tends to spread to organs that have a rich blood supply and a microenvironment that supports tumor cell colonization, with the brain, liver, and adrenal glands being classic destinations. The spleen, while it can be involved in metastasis from some cancers, is not a common site for lung cancer spread. Its immune-rich environment and splenic architecture make it a less favorable target for metastatic cells, so splenic metastases are relatively rare. If the material lists brain, liver, and adrenals as common sites, the spleen would be the one not typically included.

Lung cancer tends to spread to organs that have a rich blood supply and a microenvironment that supports tumor cell colonization, with the brain, liver, and adrenal glands being classic destinations. The spleen, while it can be involved in metastasis from some cancers, is not a common site for lung cancer spread. Its immune-rich environment and splenic architecture make it a less favorable target for metastatic cells, so splenic metastases are relatively rare. If the material lists brain, liver, and adrenals as common sites, the spleen would be the one not typically included.