Which finding is most associated with invasive mole?

Which finding is most associated with invasive mole?

• A. Preeclampsia before 20 weeks
• B. Hyperemesis gravidarum
• C. Painless vaginal bleeding
• D. Uterine size and date discrepancies

Answer: (C)

Invasive mole is a gestational trophoblastic neoplasm that persists in the uterus after a mole and invades the myometrium, often causing ongoing bleeding from the uterus. The most characteristic finding is painless vaginal bleeding, reflecting the abnormal trophoblastic tissue in the uterus shedding or eroding vessels. While things like preeclampsia before 20 weeks, hyperemesis gravidarum, or uterine size/date discrepancies can occur with molar disease, the symptom that best aligns with invasive mole’s typical presentation is vaginal bleeding without pain. Persistent or recurrent bleeding after evacuation and a rising or plateauing hCG level are also clues, but the first and most identifiable feature among these options is painless vaginal bleeding.

Invasive mole is a gestational trophoblastic neoplasm that persists in the uterus after a mole and invades the myometrium, often causing ongoing bleeding from the uterus. The most characteristic finding is painless vaginal bleeding, reflecting the abnormal trophoblastic tissue in the uterus shedding or eroding vessels. While things like preeclampsia before 20 weeks, hyperemesis gravidarum, or uterine size/date discrepancies can occur with molar disease, the symptom that best aligns with invasive mole’s typical presentation is vaginal bleeding without pain. Persistent or recurrent bleeding after evacuation and a rising or plateauing hCG level are also clues, but the first and most identifiable feature among these options is painless vaginal bleeding.