Which exam finding is characteristic of Stevens-Johnson syndrome?

Which exam finding is characteristic of Stevens-Johnson syndrome?

• A. Blistering rash and erosions on face/trunk/limbs with mucosal involvement and targetoid or purpuric lesions.
• B. Isolated scalp dandruff.
• C. Nonblistering itchy dermatitis.
• D. Hypopigmented patches.

Answer: (A)

Stevens-Johnson syndrome is a severe mucocutaneous reaction, usually triggered by a medication, that presents with widespread blistering skin involvement and damage to mucous membranes. The described finding matches this pattern: a blistering rash that involves the face, trunk, and limbs along with erosions and mucosal involvement, and lesions that are targetoid or purpuric in appearance. The combination of epidermal detachment with mucosal ulcers is the hallmark that sets SJS apart from milder skin conditions. This is a medical emergency to stop the offending drug and provide intensive supportive care, including management of oral, ocular, and genital mucosa. Dandruff, nonblistering itchy dermatitis, or hypopigmented patches lack the blistering with mucosal involvement seen in SJS.

Stevens-Johnson syndrome is a severe mucocutaneous reaction, usually triggered by a medication, that presents with widespread blistering skin involvement and damage to mucous membranes. The described finding matches this pattern: a blistering rash that involves the face, trunk, and limbs along with erosions and mucosal involvement, and lesions that are targetoid or purpuric in appearance. The combination of epidermal detachment with mucosal ulcers is the hallmark that sets SJS apart from milder skin conditions. This is a medical emergency to stop the offending drug and provide intensive supportive care, including management of oral, ocular, and genital mucosa. Dandruff, nonblistering itchy dermatitis, or hypopigmented patches lack the blistering with mucosal involvement seen in SJS.