Which autoantibody is typically detected in Goodpasture syndrome?

Which autoantibody is typically detected in Goodpasture syndrome?

• A. Anti-GBM antibodies against type IV collagen
• B. Anti-MPO antibodies
• C. Anti-dsDNA antibodies
• D. Anti-Smith antibodies

Answer: (A)

Goodpasture syndrome is driven by autoantibodies that attack the basement membranes of the kidneys and lungs. The antibody most characteristic is anti-GBM antibodies directed against the noncollagenous domain of the type IV collagen in the glomerular and alveolar basement membranes. This binding damages those membranes, leading to rapidly progressive glomerulonephritis and pulmonary hemorrhage. A hallmark finding is a linear IgG deposition along the basement membranes on immunofluorescence, and circulating anti-GBM antibodies can be detected in the serum. By contrast, anti-MPO antibodies are linked to ANCA-associated vasculitis, while anti-dsDNA and anti-Smith antibodies are associated with systemic lupus erythematosus and do not target basement membranes.

Goodpasture syndrome is driven by autoantibodies that attack the basement membranes of the kidneys and lungs. The antibody most characteristic is anti-GBM antibodies directed against the noncollagenous domain of the type IV collagen in the glomerular and alveolar basement membranes. This binding damages those membranes, leading to rapidly progressive glomerulonephritis and pulmonary hemorrhage. A hallmark finding is a linear IgG deposition along the basement membranes on immunofluorescence, and circulating anti-GBM antibodies can be detected in the serum. By contrast, anti-MPO antibodies are linked to ANCA-associated vasculitis, while anti-dsDNA and anti-Smith antibodies are associated with systemic lupus erythematosus and do not target basement membranes.