Which area is most commonly affected by vulvar cancer primary lesions?

Which area is most commonly affected by vulvar cancer primary lesions?

• A. Labia majora
• B. Labia minora
• C. Clitoris
• D. Bartholin gland

Answer: (A)

Vulvar cancers most commonly arise on the labia majora. This area is the largest external component of the vulva and contains abundant squamous epithelium, making it the common site for malignant transformation, including HPV-related precursors. While cancers can develop anywhere on the vulva, lesions of the labia majora account for the majority of primary vulvar cancers. Bartholin gland cancers are rare, and lesions on the labia minora or clitoris occur less frequently. Recognizing that the labia majora is the typical site helps guide clinical suspicion and prompt biopsy for diagnosis.

Vulvar cancers most commonly arise on the labia majora. This area is the largest external component of the vulva and contains abundant squamous epithelium, making it the common site for malignant transformation, including HPV-related precursors. While cancers can develop anywhere on the vulva, lesions of the labia majora account for the majority of primary vulvar cancers. Bartholin gland cancers are rare, and lesions on the labia minora or clitoris occur less frequently. Recognizing that the labia majora is the typical site helps guide clinical suspicion and prompt biopsy for diagnosis.