Which antibody is commonly associated with dermatomyositis?

Which antibody is commonly associated with dermatomyositis?

• A. Anti-Mi-2 antibodies
• B. Anti-Jo-1 antibodies
• C. Anti-centromere antibodies
• D. Anti-dsDNA antibodies

Answer: (B)

Dermatomyositis is often associated with specific autoantibodies known as antisynthetase antibodies, and anti-Jo-1 is the most frequently detected among inflammatory myopathies. Anti-Jo-1 targets histidyl-tRNA synthetase and defines the antisynthetase syndrome, which commonly accompanies dermatomyositis and polymyositis and is linked with features like interstitial lung disease and mechanic’s hands. While anti-Mi-2 is strongly linked to dermatomyositis and the classic rash, it is less commonly found overall. Anti-centromere antibodies relate more to limited systemic sclerosis, and anti-dsDNA is associated with SLE, not dermatomyositis.

Dermatomyositis is often associated with specific autoantibodies known as antisynthetase antibodies, and anti-Jo-1 is the most frequently detected among inflammatory myopathies. Anti-Jo-1 targets histidyl-tRNA synthetase and defines the antisynthetase syndrome, which commonly accompanies dermatomyositis and polymyositis and is linked with features like interstitial lung disease and mechanic’s hands. While anti-Mi-2 is strongly linked to dermatomyositis and the classic rash, it is less commonly found overall. Anti-centromere antibodies relate more to limited systemic sclerosis, and anti-dsDNA is associated with SLE, not dermatomyositis.