Which antibodies are associated with autoimmune thyroiditis (Hashimoto's disease)?

Which antibodies are associated with autoimmune thyroiditis (Hashimoto's disease)?

• A. Thyroid peroxidase antibodies only
• B. Anti-TSH receptor antibodies
• C. Calcitonin antibodies
• D. Thyroid peroxidase and antithyroglobulin antibodies

Answer: (D)

Hashimoto's disease involves an autoimmune attack on the thyroid, with antibodies most commonly directed against thyroid antigens such as thyroid peroxidase and thyroglobulin. Anti-thyroid peroxidase (TPO) antibodies are the most sensitive and are present in the majority of patients, while anti-thyroglobulin antibodies are also commonly found and support the autoimmune etiology. Antibodies to the TSH receptor are typically linked to Graves' disease and thyrotoxicosis, not Hashimoto's. Calcitonin antibodies are not a characteristic feature of this condition. So the antibodies associated with autoimmune thyroiditis are those targeting thyroid peroxidase and thyroglobulin.

Hashimoto's disease involves an autoimmune attack on the thyroid, with antibodies most commonly directed against thyroid antigens such as thyroid peroxidase and thyroglobulin. Anti-thyroid peroxidase (TPO) antibodies are the most sensitive and are present in the majority of patients, while anti-thyroglobulin antibodies are also commonly found and support the autoimmune etiology. Antibodies to the TSH receptor are typically linked to Graves' disease and thyrotoxicosis, not Hashimoto's. Calcitonin antibodies are not a characteristic feature of this condition. So the antibodies associated with autoimmune thyroiditis are those targeting thyroid peroxidase and thyroglobulin.