What is a standard treatment for an acute bleed in Hemophilia A?

What is a standard treatment for an acute bleed in Hemophilia A?

• A. Factor VIII infusion
• B. Desmopressin alone
• C. Vitamin K
• D. Platelet transfusion

Answer: (A)

When an acute bleed occurs in Hemophilia A, the essential approach is to replace the missing factor VIII with an infusion of Factor VIII concentrate. This directly increases the plasma FVIII level, restoring the intrinsic coagulation pathway and allowing adequate thrombin generation to form a stable clot. Desmopressin alone can raise FVIII modestly in some mild cases, but it is not reliably sufficient to control a major acute bleed. Vitamin K does not help in Hemophilia A because it addresses vitamin K–dependent factors, not factor VIII. Platelet transfusion won’t correct the underlying FVIII deficiency and is not standard first-line therapy for an acute bleed in Hemophilia A.

When an acute bleed occurs in Hemophilia A, the essential approach is to replace the missing factor VIII with an infusion of Factor VIII concentrate. This directly increases the plasma FVIII level, restoring the intrinsic coagulation pathway and allowing adequate thrombin generation to form a stable clot. Desmopressin alone can raise FVIII modestly in some mild cases, but it is not reliably sufficient to control a major acute bleed. Vitamin K does not help in Hemophilia A because it addresses vitamin K–dependent factors, not factor VIII. Platelet transfusion won’t correct the underlying FVIII deficiency and is not standard first-line therapy for an acute bleed in Hemophilia A.