Uterine dysfunction leading to amenorrhea is most commonly due to which condition?

Uterine dysfunction leading to amenorrhea is most commonly due to which condition?

• A. Endometrial cancer
• B. Adenomyosis
• C. Asherman's syndrome
• D. Leiomyoma

Answer: (C)

Amenorrhea from uterine dysfunction is most commonly caused by intrauterine adhesions, known as Asherman syndrome. When the endometrium is damaged and scar tissue forms inside the uterine cavity—often after uterine instrumentation such as dilation and curettage or postpartum procedures—the functional endometrium can’t proliferate and shed normally. The adhesions effectively reduce the surface area and disrupt normal shedding, leading to little or no menstrual flow. This pattern fits best with Asherman syndrome. The other conditions tend to produce abnormal bleeding patterns rather than a lack of menses: endometrial cancer usually presents with abnormal uterine bleeding, adenomyosis typically causes heavy, painful periods, and fibroids (leiomyoma) also commonly cause heavy or prolonged bleeding.

Amenorrhea from uterine dysfunction is most commonly caused by intrauterine adhesions, known as Asherman syndrome. When the endometrium is damaged and scar tissue forms inside the uterine cavity—often after uterine instrumentation such as dilation and curettage or postpartum procedures—the functional endometrium can’t proliferate and shed normally. The adhesions effectively reduce the surface area and disrupt normal shedding, leading to little or no menstrual flow.

This pattern fits best with Asherman syndrome. The other conditions tend to produce abnormal bleeding patterns rather than a lack of menses: endometrial cancer usually presents with abnormal uterine bleeding, adenomyosis typically causes heavy, painful periods, and fibroids (leiomyoma) also commonly cause heavy or prolonged bleeding.