Tumor Lysis Syndrome treatment includes which of the following?

Tumor Lysis Syndrome treatment includes which of the following?

• A. Allopurinol and IV fluids
• B. Antibiotics
• C. Radiation therapy
• D. Surgery

Answer: (A)

Tumor Lysis Syndrome is a metabolic emergency from rapid tumor cell breakdown, leading to dangerous electrolyte shifts and uric acid buildup. The treatment focuses on preventing kidney injury and lowering uric acid. Aggressive IV hydration keeps renal perfusion and helps flush out the metabolites, while allopurinol inhibits xanthine oxidase to reduce uric acid production. In high-risk cases, rasburicase can rapidly reduce existing uric acid levels. Antibiotics, radiation, or surgery don’t address these metabolic disturbances, so they aren’t part of TLS management.

Tumor Lysis Syndrome is a metabolic emergency from rapid tumor cell breakdown, leading to dangerous electrolyte shifts and uric acid buildup. The treatment focuses on preventing kidney injury and lowering uric acid. Aggressive IV hydration keeps renal perfusion and helps flush out the metabolites, while allopurinol inhibits xanthine oxidase to reduce uric acid production. In high-risk cases, rasburicase can rapidly reduce existing uric acid levels. Antibiotics, radiation, or surgery don’t address these metabolic disturbances, so they aren’t part of TLS management.