The most common form of primary hyperaldosteronism is idiopathic bilateral adrenal hyperplasia, representing about what percentage?

The most common form of primary hyperaldosteronism is idiopathic bilateral adrenal hyperplasia, representing about what percentage?

• A. 20%
• B. 40%
• C. 60%
• D. 80%

Answer: (C)

In primary hyperaldosteronism, the two main causes are bilateral adrenal hyperplasia (idiopathic) and a unilateral aldosterone-producing adenoma. Bilateral adrenal hyperplasia is more common because both glands enlarge and overproduce aldosterone rather than a single gland forming a focal tumor. This diffuse nature accounts for about six in ten cases, roughly 60%. Clinically, this distinction matters for treatment: bilateral disease is usually managed with mineralocorticoid receptor antagonists, while a unilateral adenoma can sometimes be cured with surgical removal.

In primary hyperaldosteronism, the two main causes are bilateral adrenal hyperplasia (idiopathic) and a unilateral aldosterone-producing adenoma. Bilateral adrenal hyperplasia is more common because both glands enlarge and overproduce aldosterone rather than a single gland forming a focal tumor. This diffuse nature accounts for about six in ten cases, roughly 60%. Clinically, this distinction matters for treatment: bilateral disease is usually managed with mineralocorticoid receptor antagonists, while a unilateral adenoma can sometimes be cured with surgical removal.