Rhabdomyolysis is usually caused by which scenario?

Rhabdomyolysis is usually caused by which scenario?

• A. Crush injury
• B. Viral infection
• C. Autoimmune disease
• D. Vitamin deficiency

Answer: (A)

Rhabdomyolysis results from rapid skeletal muscle breakdown with release of intracellular contents like myoglobin into the bloodstream. The classic trigger is a crush injury, where prolonged compression causes direct muscle fiber damage and ischemia, leading to cell rupture. This scenario best explains the common course of rhabdomyolysis and its potential kidney complications from myoglobin. While viral infections can occasionally cause muscle damage, they are not the typical precipitating scenario, and autoimmune disease or vitamin deficiencies are not common causes of acute rhabdomyolysis.

Rhabdomyolysis results from rapid skeletal muscle breakdown with release of intracellular contents like myoglobin into the bloodstream. The classic trigger is a crush injury, where prolonged compression causes direct muscle fiber damage and ischemia, leading to cell rupture. This scenario best explains the common course of rhabdomyolysis and its potential kidney complications from myoglobin. While viral infections can occasionally cause muscle damage, they are not the typical precipitating scenario, and autoimmune disease or vitamin deficiencies are not common causes of acute rhabdomyolysis.