Pernicious anemia is commonly associated with which autoimmune condition?

Pernicious anemia is commonly associated with which autoimmune condition?

• A. Hashimoto thyroiditis
• B. SLE
• C. Crohn disease
• D. Celiac disease

Answer: (A)

Pernicious anemia is caused by autoimmune destruction of gastric parietal cells and intrinsic factor, leading to impaired vitamin B12 absorption. Because of this autoimmune basis, it often clusters with other autoimmune diseases. The most commonly observed association is autoimmune thyroid disease, particularly Hashimoto thyroiditis, making this the best choice. While other autoimmune conditions like SLE, Crohn disease, or celiac disease can occur in patients with pernicious anemia, they are not as classically linked as autoimmune thyroid disease.

Pernicious anemia is caused by autoimmune destruction of gastric parietal cells and intrinsic factor, leading to impaired vitamin B12 absorption. Because of this autoimmune basis, it often clusters with other autoimmune diseases. The most commonly observed association is autoimmune thyroid disease, particularly Hashimoto thyroiditis, making this the best choice. While other autoimmune conditions like SLE, Crohn disease, or celiac disease can occur in patients with pernicious anemia, they are not as classically linked as autoimmune thyroid disease.