In sickle cell disease, which CBC pattern is expected?

In sickle cell disease, which CBC pattern is expected?

• A. Decreased Hgb and Hematocrit With Increased Reticulocytes
• B. Increased WBC
• C. Decreased Hgb With Normal Reticulocytes
• D. Normal RBC Count

Answer: (A)

Chronic hemolysis from sickle cell disease triggers the bone marrow to compensate by producing more red cells, so the CBC shows anemia with a strong reticulocytotic response. The hallmark pattern is decreased hemoglobin and hematocrit due to ongoing red cell destruction, accompanied by an increased reticulocyte count as the marrow pumps out new red cells. This combination reflects the body's attempt to replace the cells lost to hemolysis. While white blood cells can be elevated during crises or infection, and the overall RBC count can vary, the defining finding in this condition is low Hb/Hct with elevated reticulocytes.

Chronic hemolysis from sickle cell disease triggers the bone marrow to compensate by producing more red cells, so the CBC shows anemia with a strong reticulocytotic response. The hallmark pattern is decreased hemoglobin and hematocrit due to ongoing red cell destruction, accompanied by an increased reticulocyte count as the marrow pumps out new red cells. This combination reflects the body's attempt to replace the cells lost to hemolysis. While white blood cells can be elevated during crises or infection, and the overall RBC count can vary, the defining finding in this condition is low Hb/Hct with elevated reticulocytes.