In primary hypothyroidism, which laboratory pattern is typical?

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Multiple Choice

In primary hypothyroidism, which laboratory pattern is typical?

Explanation:
When the thyroid gland isn’t producing enough hormone (primary hypothyroidism), the pituitary gland tries to compensate by raising TSH to stimulate the thyroid. Because the thyroid can’t meet the demand, the circulating free T4 falls. So the classic lab picture shows an elevated TSH with a low free T4. This reflects failure at the thyroid gland level with intact pituitary feedback upregulating TSH.

When the thyroid gland isn’t producing enough hormone (primary hypothyroidism), the pituitary gland tries to compensate by raising TSH to stimulate the thyroid. Because the thyroid can’t meet the demand, the circulating free T4 falls. So the classic lab picture shows an elevated TSH with a low free T4. This reflects failure at the thyroid gland level with intact pituitary feedback upregulating TSH.

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