In Peutz-Jeghers syndrome, pigmented spots are most commonly found on which sites?

In Peutz-Jeghers syndrome, pigmented spots are most commonly found on which sites?

• A. Palms only.
• B. Genital mucosa only.
• C. Lips, inside of the mouth, around the eyes, and on the fingers and toes.
• D. On the eyelids only.

Answer: (C)

Peutz-Jeghers syndrome is marked by mucocutaneous pigmented macules that often appear in childhood and help point to the diagnosis. The spots are most commonly found where mucosa meets skin and on exposed areas of the face and extremities. The classic pattern includes the lips and the inside of the mouth, around the eyes, and on the fingers and toes. These sites—lips, oral mucosa, periorbital skin, and digits—are where the pigmentation most reliably presents, forming the characteristic distribution clinicians look for. The spots are flat, darkly pigmented freckles created by increased melanin in the affected areas, and they tend to persist over time, even though some fading can occur with age. This mucocutaneous pigment clue often precedes or accompanies the development of hamartomatous polyps in the gastrointestinal tract. While pigmentation can be seen elsewhere, the combination described is the most typical and helpful for recognition.

Peutz-Jeghers syndrome is marked by mucocutaneous pigmented macules that often appear in childhood and help point to the diagnosis. The spots are most commonly found where mucosa meets skin and on exposed areas of the face and extremities. The classic pattern includes the lips and the inside of the mouth, around the eyes, and on the fingers and toes. These sites—lips, oral mucosa, periorbital skin, and digits—are where the pigmentation most reliably presents, forming the characteristic distribution clinicians look for. The spots are flat, darkly pigmented freckles created by increased melanin in the affected areas, and they tend to persist over time, even though some fading can occur with age. This mucocutaneous pigment clue often precedes or accompanies the development of hamartomatous polyps in the gastrointestinal tract. While pigmentation can be seen elsewhere, the combination described is the most typical and helpful for recognition.