In Hashimoto's thyroiditis, which antibody profile is most typical?

In Hashimoto's thyroiditis, which antibody profile is most typical?

• A. Thyroid peroxidase and antithyroglobulin antibodies
• B. Anti-thyroglobulin antibodies only
• C. Thyroid-stimulating hormone receptor antibodies
• D. Calcitonin antibodies

Answer: (A)

Hashimoto's thyroiditis is driven by autoimmune antibodies targeting thyroid components, with anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies forming the classic pattern. Anti-TPO antibodies are the most sensitive finding in this condition and often present, while anti-thyroglobulin antibodies are also common. This combination reflects immune-mediated destruction of thyroid tissue, leading to hypothyroidism over time. Antibodies against the TSH receptor are more typical of Graves' disease, where they stimulate the receptor and cause hyperthyroidism. Calcitonin antibodies are not a hallmark of Hashimoto's. Therefore, the typical profile is both anti-TPO and anti-thyroglobulin antibodies.

Hashimoto's thyroiditis is driven by autoimmune antibodies targeting thyroid components, with anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies forming the classic pattern. Anti-TPO antibodies are the most sensitive finding in this condition and often present, while anti-thyroglobulin antibodies are also common. This combination reflects immune-mediated destruction of thyroid tissue, leading to hypothyroidism over time. Antibodies against the TSH receptor are more typical of Graves' disease, where they stimulate the receptor and cause hyperthyroidism. Calcitonin antibodies are not a hallmark of Hashimoto's. Therefore, the typical profile is both anti-TPO and anti-thyroglobulin antibodies.