In gout management, which medication is noted to decrease uric acid levels?

In gout management, which medication is noted to decrease uric acid levels?

• A. Thiazide diuretics
• B. Furosemide
• C. Captopril
• D. Losartan

Answer: (D)

In gout management, lowering serum uric acid by increasing its renal excretion is a key strategy. Losartan has a uricosuric effect: it promotes uric acid excretion in the kidneys by inhibiting reabsorption of urate in the proximal tubule, which lowers serum urate levels. This makes it the best choice for reducing uric acid among the options. Thiazide and loop diuretics raise uric acid by decreasing its excretion, captopril doesn’t meaningfully lower uric acid, so they’re not the right pick.

In gout management, lowering serum uric acid by increasing its renal excretion is a key strategy. Losartan has a uricosuric effect: it promotes uric acid excretion in the kidneys by inhibiting reabsorption of urate in the proximal tubule, which lowers serum urate levels. This makes it the best choice for reducing uric acid among the options. Thiazide and loop diuretics raise uric acid by decreasing its excretion, captopril doesn’t meaningfully lower uric acid, so they’re not the right pick.