In G6PD deficiency, which intervention may be required in severe anemia?

In G6PD deficiency, which intervention may be required in severe anemia?

• A. Blood transfusions
• B. Iron and folic acid supplements
• C. Vitamin C supplementation
• D. Platelet transfusion

Answer: (B)

During a severe hemolytic episode in G6PD deficiency, the bone marrow ramps up production of new red cells. This rapid erythropoiesis increases the need for folate, which is essential for DNA synthesis in developing erythroblasts. Providing folic acid supports the formation of new red cells and helps recovery from the anemia. Iron supplementation isn’t routinely given in this context unless there is proven iron deficiency, because iron stores can be normal or elevated after hemolysis and unnecessary iron can cause harm. So, folic acid is the key supportive measure, with iron added only if a deficiency is demonstrated. This combination reflects the typical need to support red cell production, with iron use tailored to iron status.

During a severe hemolytic episode in G6PD deficiency, the bone marrow ramps up production of new red cells. This rapid erythropoiesis increases the need for folate, which is essential for DNA synthesis in developing erythroblasts. Providing folic acid supports the formation of new red cells and helps recovery from the anemia.

Iron supplementation isn’t routinely given in this context unless there is proven iron deficiency, because iron stores can be normal or elevated after hemolysis and unnecessary iron can cause harm. So, folic acid is the key supportive measure, with iron added only if a deficiency is demonstrated. This combination reflects the typical need to support red cell production, with iron use tailored to iron status.