In erosive gastritis, which factors commonly contribute to mucosal erosion?

In erosive gastritis, which factors commonly contribute to mucosal erosion?

• A. NSAID use and alcohol consumption
• B. H. pylori infection only
• C. Viral infections only
• D. Diet high in fiber

Answer: (A)

Erosive gastritis happens when the protective mucous layer and bicarbonate production of the stomach are overwhelmed by chemical or irritant injury, leading to superficial mucosal erosions. Two classic contributors are NSAID use and alcohol consumption. NSAIDs inhibit cyclooxygenase, reducing prostaglandin synthesis. Prostaglandins help sustain the protective gastric mucus, bicarbonate, and mucosal blood flow; with less protection, acid and pepsin injure the lining, producing erosions. Alcohol directly irritates the gastric mucosa, disrupts the mucous barrier, and increases mucosal permeability, promoting erosion, especially when the mucosa is already stressed. H. pylori infection causes chronic gastritis and can lead to ulcers, but it’s not the typical driver of acute erosive injury. Viral infections are not common culprits here, and a diet high in fiber is generally not associated with mucosal erosion and may be protective.

Erosive gastritis happens when the protective mucous layer and bicarbonate production of the stomach are overwhelmed by chemical or irritant injury, leading to superficial mucosal erosions. Two classic contributors are NSAID use and alcohol consumption. NSAIDs inhibit cyclooxygenase, reducing prostaglandin synthesis. Prostaglandins help sustain the protective gastric mucus, bicarbonate, and mucosal blood flow; with less protection, acid and pepsin injure the lining, producing erosions. Alcohol directly irritates the gastric mucosa, disrupts the mucous barrier, and increases mucosal permeability, promoting erosion, especially when the mucosa is already stressed.

H. pylori infection causes chronic gastritis and can lead to ulcers, but it’s not the typical driver of acute erosive injury. Viral infections are not common culprits here, and a diet high in fiber is generally not associated with mucosal erosion and may be protective.