HLA-B27 positivity is most commonly associated with which condition that can present with anterior uveitis?

HLA-B27 positivity is most commonly associated with which condition that can present with anterior uveitis?

• A. Sarcoidosis
• B. Ankylosing spondylitis
• C. CMV infection
• D. Toxoplasmosis

Answer: (B)

HLA-B27 is a genetic marker strongly linked to seronegative spondyloarthropathies, especially ankylosing spondylitis. In these conditions, anterior uveitis is a common extra-articular manifestation, often recurrent and painful with photophobia. Because HLA-B27 positivity specifically elevates the risk of this ocular inflammation in the setting of ankylosing spondylitis, this association is the most characteristic. Other listed conditions can cause eye inflammation but do not have the same strong HLA-B27 linkage.

HLA-B27 is a genetic marker strongly linked to seronegative spondyloarthropathies, especially ankylosing spondylitis. In these conditions, anterior uveitis is a common extra-articular manifestation, often recurrent and painful with photophobia. Because HLA-B27 positivity specifically elevates the risk of this ocular inflammation in the setting of ankylosing spondylitis, this association is the most characteristic. Other listed conditions can cause eye inflammation but do not have the same strong HLA-B27 linkage.