Endometrial cancer most commonly occurs in which demographic group?

Endometrial cancer most commonly occurs in which demographic group?

• A. Adolescent girls
• B. Men
• C. Pregnant women
• D. Postmenopausal women aged 50-60

Answer: (D)

Endometrial cancer is driven by estrogen’s stimulation of the uterine lining. The group most at risk is women after menopause, especially around ages 50 to 60. After menopause, factors like obesity or ongoing exposure to estrogen (including some hormone therapies) can create unopposed estrogen stimulation of the endometrium, promoting proliferation that can lead to cancer. Most patients present with abnormal uterine bleeding after menopause. This cancer is very uncommon in adolescent girls, in men, or during pregnancy, making the postmenopausal 50–60 age range the typical demographic.

Endometrial cancer is driven by estrogen’s stimulation of the uterine lining. The group most at risk is women after menopause, especially around ages 50 to 60. After menopause, factors like obesity or ongoing exposure to estrogen (including some hormone therapies) can create unopposed estrogen stimulation of the endometrium, promoting proliferation that can lead to cancer. Most patients present with abnormal uterine bleeding after menopause. This cancer is very uncommon in adolescent girls, in men, or during pregnancy, making the postmenopausal 50–60 age range the typical demographic.