Delayed ejaculation is commonly associated with which class of antidepressants?

Delayed ejaculation is commonly associated with which class of antidepressants?

• A. SNRIs
• B. SSRIs
• C. TCAs
• D. MAOIs

Answer: (B)

Selective serotonin reuptake inhibitors cause delayed ejaculation because they raise serotonin levels in the brain by blocking its reuptake. Higher central serotonin activity dampens the ejaculatory reflex, slowing or delaying emission and ejaculation. This side effect is a hallmark of SSRI use, making them the class most commonly linked to delayed ejaculation. Other antidepressants can affect sexual function too, but the pronounced delay in ejaculation is most characteristic of the serotonin-driven effects of SSRIs.

Selective serotonin reuptake inhibitors cause delayed ejaculation because they raise serotonin levels in the brain by blocking its reuptake. Higher central serotonin activity dampens the ejaculatory reflex, slowing or delaying emission and ejaculation. This side effect is a hallmark of SSRI use, making them the class most commonly linked to delayed ejaculation. Other antidepressants can affect sexual function too, but the pronounced delay in ejaculation is most characteristic of the serotonin-driven effects of SSRIs.